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An in-vitro study found that berberine protected NSC34 cells from H 2 O 2 -induced cytotoxicity by reducing ROS production, restoring glutathione, and superoxide dismutase activity, and activating the production of antioxidant proteins nuclear factor erythroid 2-related factor-2 (Nrf2) and HO-1 (Hsu et al., 2012

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The presence of high glucose levels further exacerbates this interaction, as glucose serves as a nutrient for bacteria and promotes the release of inflammatory mediators, which, in turn, damage surrounding tissues, as depicted in Fig

The NLRP3 inflammasome: mechanism of action, role in disease and therapies